How Protein Shapes Help Us Make Medicine
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Coming up with brand new drugs is all about pinpointing and exploiting a diseases weakness. A big part of perfecting drug design will be learning to predict how proteins get their shapes because that has everything to do with how both diseases and drugs work.
Hosted by: Hank Green
SciShow has a spinoff podcast! It's called SciShow Tangents. Check it out at http://www.scishowtangents.org
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Support SciShow by becoming a patron on Patreon: https://www.patreon.com/scishow
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Huge thanks go to the following Patreon supporters for helping us keep SciShow free for everyone forever:
Adam Brainard, Greg, Alex Hackman, Sam Lutfi, D.A. Noe, , Piya Shedden, KatieMarie Magnone, Scott Satovsky Jr, Charles Southerland, Patrick D. Ashmore, charles george, Kevin Bealer, Chris Peters
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Sources:
https://www.pbs.org/newshour/health/the-real-story-behind-the-worlds-first-antibiotic
https://www.cancer.gov/research/progress/discovery/gleevec
https://www.nature.com/scitable/topicpage/gleevec-the-breakthrough-in-cancer-treatment-565
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055302/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5238551/
https://www.ncbi.nlm.nih.gov/pubmed/17921997
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4889822/
http://www.rcsb.org/pdb/results/results.do?tabtoshow=Current&qrid=69B25B99
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC138819/pdf/gb-2000-1-1-comment002.pdf
https://science.sciencemag.org/content/294/5540/93
https://www.biostat.wisc.edu/bmi776/lectures/Rosetta.pdf
https://onlinelibrary.wiley.com/doi/full/10.1002/prot.25415
https://commons.wikimedia.org/wiki/File:TOP7-rosetta_superposition.png
https://commons.wikimedia.org/wiki/File:HSQC-NMR.tiff
https://commons.wikimedia.org/wiki/File:X-ray_diffraction_pattern_3clpro.jpg
https://www.nature.com/articles/nrd941
https://commons.wikimedia.org/wiki/File:Spombe_Pop2p_protein_structure_rainbow.png
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1186895/
https://www.ncbi.nlm.nih.gov/books/NBK22393/
https://academic.oup.com/bioinformatics/article/23/6/717/418732
Image Sources:
https://en.wikipedia.org/wiki/Amino_acid#/media/File:Amino_Acids.svg
https://commons.wikimedia.org/wiki/File:Imatinib_xtal-2007-balls-and-sticks.png
https://commons.wikimedia.org/wiki/File:Bruker_Avance_DPX_250_NMR_Spectrometer.jpg
Coming up with brand new drugs is all about pinpointing and exploiting a diseases weakness. A big part of perfecting drug design will be learning to predict how proteins get their shapes because that has everything to do with how both diseases and drugs work.
Hosted by: Hank Green
SciShow has a spinoff podcast! It's called SciShow Tangents. Check it out at http://www.scishowtangents.org
----------
Support SciShow by becoming a patron on Patreon: https://www.patreon.com/scishow
----------
Huge thanks go to the following Patreon supporters for helping us keep SciShow free for everyone forever:
Adam Brainard, Greg, Alex Hackman, Sam Lutfi, D.A. Noe, , Piya Shedden, KatieMarie Magnone, Scott Satovsky Jr, Charles Southerland, Patrick D. Ashmore, charles george, Kevin Bealer, Chris Peters
----------
Looking for SciShow elsewhere on the internet?
Facebook: http://www.facebook.com/scishow
Twitter: http://www.twitter.com/scishow
Tumblr: http://scishow.tumblr.com
Instagram: http://instagram.com/thescishow
----------
Sources:
https://www.pbs.org/newshour/health/the-real-story-behind-the-worlds-first-antibiotic
https://www.cancer.gov/research/progress/discovery/gleevec
https://www.nature.com/scitable/topicpage/gleevec-the-breakthrough-in-cancer-treatment-565
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055302/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5238551/
https://www.ncbi.nlm.nih.gov/pubmed/17921997
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4889822/
http://www.rcsb.org/pdb/results/results.do?tabtoshow=Current&qrid=69B25B99
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC138819/pdf/gb-2000-1-1-comment002.pdf
https://science.sciencemag.org/content/294/5540/93
https://www.biostat.wisc.edu/bmi776/lectures/Rosetta.pdf
https://onlinelibrary.wiley.com/doi/full/10.1002/prot.25415
https://commons.wikimedia.org/wiki/File:TOP7-rosetta_superposition.png
https://commons.wikimedia.org/wiki/File:HSQC-NMR.tiff
https://commons.wikimedia.org/wiki/File:X-ray_diffraction_pattern_3clpro.jpg
https://www.nature.com/articles/nrd941
https://commons.wikimedia.org/wiki/File:Spombe_Pop2p_protein_structure_rainbow.png
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1186895/
https://www.ncbi.nlm.nih.gov/books/NBK22393/
https://academic.oup.com/bioinformatics/article/23/6/717/418732
Image Sources:
https://en.wikipedia.org/wiki/Amino_acid#/media/File:Amino_Acids.svg
https://commons.wikimedia.org/wiki/File:Imatinib_xtal-2007-balls-and-sticks.png
https://commons.wikimedia.org/wiki/File:Bruker_Avance_DPX_250_NMR_Spectrometer.jpg
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