There are some things you wouldn't wish upon even your worst enemy. Stepping on Legos being no such exception. The mind bending pain of a bare foot pressing down on a Lego is one of the worst known to humanity, but how does something so innocent looking create such an intense feeling? We're talking nociception today folks, and the chemistry of how these little two gram blocks pack enough punch to send you into orbit.
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Smidi - Intergalactic Funk
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Brian Walitt, Ph.D.
Darcy Gentleman, Ph.D.
Intro to pain pathways - https://www.ucl.ac.uk/anaesthesia/StudentsandTrainees/PainPathwaysIntroduction
On Pain Signaling - https://www.mentalhelp.net/articles/what-causes-pain/
Basics of Pain - http://neuroscience.uth.tmc.edu/s2/chapter06.html
What legos are made of - http://www.wired.com/2015/07/sorry-perfect-lego-brick-may-never-eco-friendly/
Chemistry of Legos - https://jameskennedymonash.wordpress.com/2014/07/15/how-are-lego-bricks-made-the-chemistry-of-lego/
A Delta and C fibers - http://www.ncbi.nlm.nih.gov/pubmed/20886070
Pain transmittion in the periphery - http://www.anaesthetist.com/icu/pain/Findex.htm#pain3.htm
Glutamate's role in nociception - http://www.ncbi.nlm.nih.gov/pubmed/11465012
Molecules involved with pain - http://thebrain.mcgill.ca/flash/i/i_03/i_03_m/i_03_m_dou/i_03_m_dou.html
Nociceptors and Danger - http://www.ncbi.nlm.nih.gov/pubmed/17678850