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Why Does Stepping On a Lego Hurt So Bad?

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 Chemistry   |   Science
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There are some things you wouldn't wish upon even your worst enemy. Stepping on Legos being no such exception. The mind bending pain of a bare foot pressing down on a Lego is one of the worst known to humanity, but how does something so innocent looking create such an intense feeling? We're talking nociception today folks, and the chemistry of how these little two gram blocks pack enough punch to send you into orbit.

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Music:
Smidi - Intergalactic Funk
Sam Leopard - Je Trace Ma Route

Writer/Producer:
Kirk Zamieroski

Executive Producer:
Adam Dylewski

Scientific consultants:
Brian Walitt, Ph.D.
Sophia Cai
Darcy Gentleman, Ph.D.

SOURCES:

Intro to pain pathways - https://www.ucl.ac.uk/anaesthesia/StudentsandTrainees/PainPathwaysIntroduction

On Pain Signaling - https://www.mentalhelp.net/articles/what-causes-pain/

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2964977/

Basics of Pain - http://neuroscience.uth.tmc.edu/s2/chapter06.html

What legos are made of - http://www.wired.com/2015/07/sorry-perfect-lego-brick-may-never-eco-friendly/

Chemistry of Legos - https://jameskennedymonash.wordpress.com/2014/07/15/how-are-lego-bricks-made-the-chemistry-of-lego/

A Delta and C fibers - http://www.ncbi.nlm.nih.gov/pubmed/20886070

Pain transmittion in the periphery - http://www.anaesthetist.com/icu/pain/Findex.htm#pain3.htm

Glutamate's role in nociception - http://www.ncbi.nlm.nih.gov/pubmed/11465012

Molecules involved with pain - http://thebrain.mcgill.ca/flash/i/i_03/i_03_m/i_03_m_dou/i_03_m_dou.html

Nociceptors and Danger - http://www.ncbi.nlm.nih.gov/pubmed/17678850

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