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Charles II of Spain had disabilities probably caused by inbreeding in the House of Habsburg

The House of Habsburg was a family of dukes, kings, and monarchs that was very important in European history. It first ruled parts of Switzerland in the 13th century and then ruled Austria, later Austria-Hungary, for more than 600 years. It ruled owned Spain and the Netherlands for a while, the Holy Roman Empire from about 1280 to 1806 and the Kingdom of Sardinia until the mid-19th century.