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The skull and crossbones is a common symbol for toxicity

Toxicity is the degree to which a substance can damage an organism. It is the subject-matter of toxicology.

A central idea in toxicology is that almost everything is toxic when taken to excess. Effects are dose-dependent: even water can lead to 'water intoxication' when taken in too much. For even a very toxic substance such as elapid snake venom there is a dose below which there is no toxic effect.