Dragon's Blood Could Save Your Life
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Chemists have found potential drugs and other really useful compounds in some truly bizarre places in nature, and who would have ever thought that blood from the Komodo dragon could have a secret inside of it that could possibly save your life. But it doesn't end there, so we're taking a closer look at other wild places in nature that we've found fantastic drugs!
Find us on all these places:
Subscribe! http://bit.ly/ACSReactions
Facebook! http://facebook.com/ACSReactions
Twitter! http://twitter.com/ACSReactions
Tumblr! http://tumblr.com/ACSReactions
Writer/Producer:
Kirk Zamieroski
Executive Producer:
Adam Dylewski
Scientific consultants:
Al Segars, Ph.D.
Jacqueline Fries, Ph.D.
John Yates, Ph.D.
Darcy Gentleman, Ph.D.
Kyle Nackers
Music:
Roberto Daglio - Con Todo Meu Amor
Smidi - Cadillac Candy
Special Thanks to Schoolyard Films for giving us the awesome Horseshoe Crab Blood milking footage. See their in depth video on horseshoe crabs here:
https://florida.pbslearningmedia.org/resource/7fc02c9a-5678-4eab-9d10-0485fe66363e/horseshoe-crabs-prehistoric-paramedics/#.WWTKucaB2_U
SOURCES:
Antibacterial resistance - https://www.cdc.gov/getsmart/community/about/antibiotic-resistance-faqs.html
Komodo Dragon’s Blood - https://www.acs.org/content/acs/en/pressroom/presspacs/2017/acs-presspac-february-22-2017/antimicrobial-substances-identified-in-Komodo-dragon-blood.html
Biofilms - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2732559/
& https://www.ncbi.nlm.nih.gov/pubmed/23635385
Antimicrobials in Komodo Dragon blood - http://pubs.acs.org/doi/abs/10.1021/acs.jproteome.6b00857
VK25 inspires the DRGN-1 peptide - https://www.nature.com/articles/s41522-017-0017-2
DRGN-1 Kills biofilms - https://www.asm.org/index.php/2015-12-11-13-38-57/2-uncategorised/94002-antimicrobial-properties-of-peptides-derived-from-reptiles
MRSA is getting crazy - https://thefern.org/ag_insider/pig-related-infections-spread-denmark-may-u-s/
Dendrilla Membrosa - http://pubs.acs.org/doi/abs/10.1021/np50123a020
Darwinolide Story - https://phys.org/news/2016-06-antarctic-sponge-deadly-mrsa-infection.html
Darwinolide - http://pubs.acs.org/doi/full/10.1021/acs.orglett.6b00979?src=recsys
Horseshoe crabs “over 300 million years old” - https://www.nwf.org/Wildlife/Wildlife-Library/Invertebrates/Horseshoe-Crab.aspx
3-15% die, based on interviews with biologists -
http://www.radiolab.org/story/213797-krulwich-wonders-what-vampire-said-horseshoe-crab-your-blood-blue/
Evolutionary info on horseshoe crabs -
http://pubs.acs.org/doi/full/10.1021/pr1002033
The original 1956 paper by Frederick Bang that got everything going -
https://web.archive.org/web/20090719101429/http://www.mbl.edu:80/marine_org/images/animals/Limulus/Bang/index.html
How Blue Blood coagulates around endotoxins -
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3756735/
Crab Bleeding - http://www.popularmechanics.com/science/health/a26038/the-blood-of-the-crab/
LAL v TAL
http://bio.lonza.com/uploads/tx_mwaxmarketingmaterial/Lonza_AppNotesTossSheets_FDA_and_USP_can_help_promote_horseshoe_crab_conservation.pdf
Hemocyanin - http://www.jbc.org/content/276/19/15563.full
Chemists have found potential drugs and other really useful compounds in some truly bizarre places in nature, and who would have ever thought that blood from the Komodo dragon could have a secret inside of it that could possibly save your life. But it doesn't end there, so we're taking a closer look at other wild places in nature that we've found fantastic drugs!
Find us on all these places:
Subscribe! http://bit.ly/ACSReactions
Facebook! http://facebook.com/ACSReactions
Twitter! http://twitter.com/ACSReactions
Tumblr! http://tumblr.com/ACSReactions
Writer/Producer:
Kirk Zamieroski
Executive Producer:
Adam Dylewski
Scientific consultants:
Al Segars, Ph.D.
Jacqueline Fries, Ph.D.
John Yates, Ph.D.
Darcy Gentleman, Ph.D.
Kyle Nackers
Music:
Roberto Daglio - Con Todo Meu Amor
Smidi - Cadillac Candy
Special Thanks to Schoolyard Films for giving us the awesome Horseshoe Crab Blood milking footage. See their in depth video on horseshoe crabs here:
https://florida.pbslearningmedia.org/resource/7fc02c9a-5678-4eab-9d10-0485fe66363e/horseshoe-crabs-prehistoric-paramedics/#.WWTKucaB2_U
SOURCES:
Antibacterial resistance - https://www.cdc.gov/getsmart/community/about/antibiotic-resistance-faqs.html
Komodo Dragon’s Blood - https://www.acs.org/content/acs/en/pressroom/presspacs/2017/acs-presspac-february-22-2017/antimicrobial-substances-identified-in-Komodo-dragon-blood.html
Biofilms - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2732559/
& https://www.ncbi.nlm.nih.gov/pubmed/23635385
Antimicrobials in Komodo Dragon blood - http://pubs.acs.org/doi/abs/10.1021/acs.jproteome.6b00857
VK25 inspires the DRGN-1 peptide - https://www.nature.com/articles/s41522-017-0017-2
DRGN-1 Kills biofilms - https://www.asm.org/index.php/2015-12-11-13-38-57/2-uncategorised/94002-antimicrobial-properties-of-peptides-derived-from-reptiles
MRSA is getting crazy - https://thefern.org/ag_insider/pig-related-infections-spread-denmark-may-u-s/
Dendrilla Membrosa - http://pubs.acs.org/doi/abs/10.1021/np50123a020
Darwinolide Story - https://phys.org/news/2016-06-antarctic-sponge-deadly-mrsa-infection.html
Darwinolide - http://pubs.acs.org/doi/full/10.1021/acs.orglett.6b00979?src=recsys
Horseshoe crabs “over 300 million years old” - https://www.nwf.org/Wildlife/Wildlife-Library/Invertebrates/Horseshoe-Crab.aspx
3-15% die, based on interviews with biologists -
http://www.radiolab.org/story/213797-krulwich-wonders-what-vampire-said-horseshoe-crab-your-blood-blue/
Evolutionary info on horseshoe crabs -
http://pubs.acs.org/doi/full/10.1021/pr1002033
The original 1956 paper by Frederick Bang that got everything going -
https://web.archive.org/web/20090719101429/http://www.mbl.edu:80/marine_org/images/animals/Limulus/Bang/index.html
How Blue Blood coagulates around endotoxins -
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3756735/
Crab Bleeding - http://www.popularmechanics.com/science/health/a26038/the-blood-of-the-crab/
LAL v TAL
http://bio.lonza.com/uploads/tx_mwaxmarketingmaterial/Lonza_AppNotesTossSheets_FDA_and_USP_can_help_promote_horseshoe_crab_conservation.pdf
Hemocyanin - http://www.jbc.org/content/276/19/15563.full
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